Treatment Trials

MAPrc researchers regularly seek people who have experience with mental illness, as well as those who do not, for participation in research projects and treatment trials.  See the drop-down menu above (under Treatment Trials) for details of current projects requiring research participants.

What is involved in participating will depend on the project, but it might involve one or more of the following:

Any personal information provided, and the record of participation, is treated as private health information and kept confidential.

All MAPrc studies have been approved, and are governed by, the Alfred Hospital Ethics Committee.

If you would like to out forward a general expression of interest in participating in any of our research projects, please contact our centre on +61 (0)3 9076 6564 or email maprc@monash.edu

 

Complex Trauma Disorder (Borderline Personality Disorder)

 

Current treatment trials for Complex Trauma Disorder:

The Alison Project: understanding Complex Trauma Disorder and the role of Memantine

 

 

Resources for Complex Trauma Disorder:

1. How To Treat: Borderline Personality Disorder (Australian Doctor). This article was originally published by Australian Doctor. To see other articles like this click here.
 
 

Depression

MAPrc’s researchers are currently working on a number of projects investigating new diagnostic and treatment methods for people experiencing depression

The following projects are currently recruiting participants. Please contact us if you wish to receive futher information or take part in a project.


 
 
Tibolone and Escitalopram in Perimenopausal Depression
Clinical trials of a hormone treatment called Tibolone, for the treatment of depression in peri and post menopause. To take part in this study you must be physically well, aged 45-65 be experiencing depression and able to give informed consent. For further details click here or contact Emmy Gavrilidis on 9076 6913 or email emmy.gavrilidis@monash.edu
 

 
Transcranial magnetic stimulation (TMS) for Depression
TMS uses magnetic pulses to change activity in the areas of the brain thought to be related to this illness, and is being investigated as an alternative treatment for people, who have not responded to antidepressant medication. For further information click here or contact the TMS team on 90766595 or email tms-enquiry@monash.edu
 

 
 
Magnetic Seizure Therapy (MST) for Depression
MST uses a magnetic field to induce a seizure for therapeutic purposes, and is being investigated as an alternative to Electroconvulsive therapy for severe depression. For further information click here or contact the TMS team on 90766595 or email tms-enquiry@monash.edu
 

 

Deep Brain Stimulation for Depression

Deep Brain Stimulation involves the precise implantation of very small electrodes into specific areas of the brain, in an attempt to change activity in those and related areas and improve the symptoms of very severe, treatment-resistant depression.

 

As DBS is considered a treatment of last resort, only individuals who have trialled all less invasive antidepressant treatments and remained severely depressed can be considered for the procedure, This means having trialled multiple medications from all antidepressant drug classes, combinations of antidepressant medications, cognitive behavioural therapy, transcranial magnetic stimulation and extensive electroconvulsive therapy (ECT).

 

If you wish to be considered for the program, and you have tried all of the treatments listed above, you can have your psychiatrist send a detailed referral letter to Prof. Paul Fitzgerald at paul.fitzgerald@monash.edu 

 

 
EVestG (ElectrovestibuloGraphy)
A new technique, EVestG (ElectrovestibuloGraphy) in being investigated as a possible objective method for diagnosing participants with depression. For further information click here or contact MAPrc on 9076 6564 or email maprc@monash.edu 
 

 
  
Mood and Oral Contraceptives 
An observational study of women taking / not taking hormonal contraception (i.e. COCP, POP, Implanon, DMPA) exploring current mood & risk and resistance factors for adverse mood change. To take part in this study you must be a female 18 years of age or older, able to give informed consent and not currently pregnant, breast-feeding or menopausal. For further information click here or contact Natalie Thomas on 9076 5033 or email natalie.thomas@monash.edu 
 

 
NRAMP - National Register of Antipsychotic Medication in Pregnancy
An observational study for women who are taking or have taken antipsychotic medications during their pregnancy. For further information click here or contact Heather Gilbert 9076 6591 or email heather.gilbert@monash.edu 
 

 
Auditory verbal hallucinations
 A large-scale phenomenological study investigating the physical characteristics as well as underlying beliefs related to auditory verbal hallucinations, also known as 'voice-hearing' experiences, in diverse clinicial populations, including bipolar disorder, major depression and schizophrenia, as well as non-clinical groups. For further information click here or contact Dr Wei Lin Toh on 9076 5712 or wei.lin.toh@monash.edu 
 
 

 

 

 

Schizophrenia

 MAPrc’s researchers are currently working on a number of projects investigating new treatment methods for people experiencing schizophrenia

The following projects are currently recruiting participants. Please contact us if you wish to receive futher information or take part in a project.


 
Smoking Cessation/Harm reduction using Vaporised Nicotine
24 week smoking harm reduction study trialling e-cigarettes and inhalators for people with severe persistant mental illness including psychosis disorders. For more information click here or contact Gayan De Mel on
tel: (03) 9067 8045 or email gayan.demel@monash.edu
 
 
Adjunctive SERM Hormone Treatment for Men and Women with Schizophrenia and Schizoaffective Disorder
Men and women who are 18 and over, with schizophrenia or schizoaffective disorder, are invited to take part in a 12-week adjunctive treatment study that is underway in Melbourne. Hormones are known to play a role in the expression of schizophrenia and related disorders. The Monash Alfred Psychiatry research centre is investigating whether a medication that targets hormone receptors in the brain, when taken in combination with regular antipsychotic medication, can better improve psychotic symptoms, mood and cognitive functioning. Participants will be reimbursed for their time and travel can be negotiated. For further details click here or contact Amelia Arnold on (03) 9076 6589 or via email amelia.arnold@monash.edu
 
NRAMP - National Register for Antipsychotics in Pregnancy
Observational study of women who are taking or have taken antipsychotic medications during their pregnancy. For further information click here or contact Heather Gilbert on 9076 6591 or email heather.gilbert@monash.edu 
 
EVestG (ElectrovestibuloGraphy)
We are currently trialling a new technique, EVestG (ElectrovestibuloGraphy) which is being investigated as a possible objective method for diagnosing participants with Schizophrenia.  For further information click here or contact MAPrc on 9076 6564 or email maprc@monash.edu 
 
Genes and brain function
A large collaborative investigation examining how genes and brain function influence the production of language symptoms, including auditory hallucinations and confused speech.  For futher information click here or contact Dr Wei Lin Toh on 9076 6564 or email wei.lin.toh@monash.edu
 
Computer-based cognitive training for people with schizophrenia or schizoaffective disorder
We are interested in the unique benefits of cognitive training for people with schizophrenia or schizoaffective disorder when compared to regular computer games. Computer sessions are offered in groups. Participants may be allocated to either the training group or the computer game group. Please contact Shayden Bryce on 0424515907 or shayden.bryce@monash.edu for more information.
 
SAVVy: Smartphone-Assisted coping focused interVention for Voices
We are investigating the effects of a short psychological therapy which aims to help people cope with distressing voice hearing experiences. This therapy involves four face-to-face sessions with a therapist along-side the use of a smartphone app between sessions. Participants will be allocated to receive the therapy or a control group who will not receive the therapy. For more information, please visit the trial website (www.savvyresearchtrial.com) or contact Imogen Bell on (03) 9076 6564 or savvyresearchtrial@gmail.com.
 

Bipolar Disorder

MAPrc’s researchers are currently working on a number of projects investigating new diagnostic and treatment methods for people experiencing bipolar disorders, the details of which can be found below

The following projects are currently recruiting participants.  Please contact us if you wish to receive futher information or to take part in a project.


  
 
EVestG (ElectrovestibuloGraphy)
We are currently trialling a new technique, EVestG (ElectrovestibuloGraphy) as an objective method for diagnosing participants with bipolar affective disorder. For further information click here or contact MAPrc on 9076 6564 or email maprc@monash.edu
 
 
NRAMP - National Register of Antipsychotic Medication in Pregnancy
Observational study for women who are taking or have taken antipsychotic medications during their pregnancy. For further information click here or contact Heather Gilbert on 9076 6591 or email heather.gilbert@monash.edu
 
Auditory verbal hallucinations
A large-scale phenomenological study investigating the physical characteristics as well as underlying beliefs related to auditory verbal hallucinations, also known as 'voice-hearing' experiences, in diverse clinicial populations, including bipolar disorder, major depression and schizophrenia, as well as non-clinical groups. For further information click here or contact Dr Wei Lin Toh on 9076 5712 or wei.lin.toh@monash.edu 

 

Other Mental Illnesses

The following projects are currently recruiting participants. Please contact us if you wish to receive futher information or take part in a project.

Anxiety Disorders

MAPrc’s researchers are currently working on a number of projects investigating new treatment methods for people experiencing anxiety disorders, and the underlying brain mechanisms involved in the experience of anxiety symptoms.
 
Research Available at MAPrc: