Depression

MAPrc’s researchers are currently working on a number of projects investigating new diagnostic and treatment methods for people experiencing depression

The following projects are currently recruiting participants. Please contact us if you wish to receive information or take part in a project.


  
Tibolone and Escitalopram in Perimenopausal Depression
Clinical trials of a hormone treatment called Tibolone, for the treatment of depression in peri and post menopause. To take part in this study you must be physically well, aged 45-65 be experiencing depression and able to give informed consent. For further details click here or contact Caitlin Bleeker on 9076 6564 or email maprc.wmhresearch@monash.edu


 
Transcranial magnetic stimulation (TMS) for Depression
TMS uses magnetic pulses to change activity in the areas of the brain thought to be related to this illness, and is being investigated as an alternative treatment for people, who have not responded to antidepressant medication. For further information click here or contact the TMS team on 9076 8538 or email tms-enquiry@monash.edu

 
Deep Brain Stimulation for Depression
Deep Brain Stimulation involves the precise implantation of very small electrodes into specific areas of the brain, in an attempt to change activity in those and related areas and improve the symptoms of very severe, treatment-resistant depression.
 
As DBS is considered a treatment of last resort, only individuals who have trialled all less invasive antidepressant treatments and remained severely depressed can be considered for the procedure, This means having trialled multiple medications from all antidepressant drug classes, combinations of antidepressant medications, cognitive behavioural therapy, transcranial magnetic stimulation and extensive electroconvulsive therapy (ECT).
 
If you wish to be considered for the program, and you have tried all of the treatments listed above, you can have your psychiatrist send a detailed referral letter to Prof. Paul Fitzgerald at paul.fitzgerald@monash.edu

 
EVestG (ElectrovestibuloGraphy)
A new technique, EVestG (ElectrovestibuloGraphy) in being investigated as a possible objective method for diagnosing participants with depression. For further information click here or contact MAPrc on 9076 6564 or email maprc@monash.edu 

   
Mood and Oral Contraceptives 
An observational study of women taking / not taking hormonal contraception (i.e. COCP, POP, Implanon, DMPA) exploring current mood & risk and resistance factors for adverse mood change. To take part in this study you must be a female 18 years of age or older, able to give informed consent and not currently pregnant, breast-feeding or menopausal. For further information click here or contact Natalie Thomas on 9076 5033 or email natalie.thomas@monash.edu 

 
National Register of Antipsychotic Medication in Pregnancy (NRAMP)
An observational study aimed at evaluating the safety of antipsychotic medications for mothers and babies during pregnancy. NRAMP aims to develop evidence-based guidelines for the best use and effect of antipsychotic medications during pregnancy, birth, and postnatal phase, thereby assisting healthcare professionals and women with mental illness to make informed decisions about appropriate treatment options and encourage safer outcomes for mother and baby. For further information or to find out how you can participate in the study click here or contact Ms Alisa Turbic 9076 6591 or email maprc-nramp@monash.edu

 
Auditory verbal hallucinations
 A large-scale phenomenological study investigating the physical characteristics as well as underlying beliefs related to auditory verbal hallucinations, also known as 'voice-hearing' experiences, in diverse clinicial populations, including bipolar disorder, major depression and schizophrenia, as well as non-clinical groups. For further information click here or contact Dr Wei Lin Toh on 9076 5712 or wei.lin.toh@monash.edu