MAPrc’s researchers are currently working on a number of projects investigating new diagnostic and treatment methods for people experiencing depression




The following projects are currently recruiting participants. Please contact us if you wish to receive information or take part in a project.

 This is an industry sponsored clinical trial of a new class of medications that could help in the treatment of depression associated with menopause. To be eligible women must be experiencing current menopause symptoms, such as hot flushes, and have a diagnosis of major depression. Contact our friendly staff for more details and to find out if you might be eligible to participate. Email us at: 



Clinical trial of Nitrous Oxide (laughing gas) treatment for the treatment of MDD has commenced at MAPrc in December 2018. To take part in the study you must be at least 18 years old, be experiencing MDD without psychosis, and have been stable on depression medication for at least 4 weeks. For further details, please contact Ms Alisa Turbic on 9076 6591 or email

Tibolone and Escitalopram in Perimenopausal Depression
Clinical trials of a hormone treatment called Tibolone, for the treatment of depression in peri and post menopause. To take part in this study you must be physically well, aged 45-65 be experiencing depression and able to give informed consent. For further details click here or contact Caitlin Bleeker on 9076 6564 or email

Transcranial magnetic stimulation (TMS) for Depression
TMS uses magnetic pulses to change activity in the areas of the brain thought to be related to this illness, and is being investigated as an alternative treatment for people, who have not responded to antidepressant medication. For further information click here or contact the TMS team on 9076 8538 or email

Deep Brain Stimulation for Depression
Deep Brain Stimulation involves the precise implantation of very small electrodes into specific areas of the brain, in an attempt to change activity in those and related areas and improve the symptoms of very severe, treatment-resistant depression.
As DBS is considered a treatment of last resort, only individuals who have trialled all less invasive antidepressant treatments and remained severely depressed can be considered for the procedure, This means having trialled multiple medications from all antidepressant drug classes, combinations of antidepressant medications, cognitive behavioural therapy, transcranial magnetic stimulation and extensive electroconvulsive therapy (ECT).
If you wish to be considered for the program, and you have tried all of the treatments listed above, you can have your psychiatrist send a detailed referral letter to Prof. Paul Fitzgerald at

EVestG (ElectrovestibuloGraphy)
A new technique, EVestG (ElectrovestibuloGraphy) in being investigated as a possible objective method for diagnosing participants with depression. For further information click here or contact MAPrc on 9076 6564 or email 

Mood and Oral Contraceptives 
An observational study of women taking / not taking hormonal contraception (i.e. COCP, POP, Implanon, DMPA) exploring current mood & risk and resistance factors for adverse mood change. To take part in this study you must be a female 18 years of age or older, able to give informed consent and not currently pregnant, breast-feeding or menopausal. For further information click here or contact Natalie Thomas on 9076 5033 or email 

National Register of Antipsychotic Medication in Pregnancy (NRAMP)
An observational study aimed at evaluating the safety of antipsychotic medications for mothers and babies during pregnancy. NRAMP aims to develop evidence-based guidelines for the best use and effect of antipsychotic medications during pregnancy, birth, and postnatal phase, thereby assisting healthcare professionals and women with mental illness to make informed decisions about appropriate treatment options and encourage safer outcomes for mother and baby. For further information or to find out how you can participate in the study click here or email





 MAPrc Monash Alfred Psychiatry Research Centre, Level 4, 607 St Kilda Road, Melbourne 3004

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